BRCA

1 in 400 to 800 men and women in the general populations carry BRCA1 or BRCA2 mutations.
Risk is higher in men and women of Ashkenazi Jewish descent (1 in 40 chance)

BRCA1 - breast, ovarian, melanoma, colon

PARP inhibitors - poly ADP ribose polymerace - block an enzyme used by cancer cells to repair damage to their DNA.  Shows promise in patients with inherited BRCA mutations and BRCA abnormalities.

• Lynparza (olaparib)
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