Lynch Syndrome

A hereditary disorder caused by a genetic mutation that predisposes a person to several cancers, including colon, stomach, pancreas, kidneys, brain, uterus and skin.

One out of every 279 people has it.
Lynch syndrome accounts for 2-4% of colon cancer cases in US and 2-5% endometrial cancers in women.
If a person tests positive for Lynch syndrome, their children have a 50% chance of inheriting the mutation

• MLH1
• MSH2
• MLH1 and MSH2 face a lifetime risk of developing colon cancer between 52-82% (compared with 4.8 for general population)
• MSH6 - women have 25-60% lifetime risk of developing endometrial cancer
• PMS2
• EOCAM

All genes involved in the process of DNA repair.